Now that the market has an increase in products with cannabidiol (CBD), the research of the drug still continues to better understand its effectivity. Compared to THC products, CBD oil produces few side effects.

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Even though the researchers still states that CBD oil is safe to use and does not give a major risk when used chronically or acute. There are exemptions such as interacting with other drugs that are not compatible with CBD. One of these risks is the inhibition of the cytochrome P450 enzyme in the system.

What is the Cytochrome P-450 System?

The cytochrome P450 enzymes function is to metabolize potentially toxic compounds. This includes drugs and products of endogenous metabolism such as bilirubin, mainly in the liver. 60% percent of any drugs consumed are processed by the Cytochrome P-450.

The Use of Cytochrome P-450 with CBD Oil?

Doctors may take time in calculating the right amount of dosage when prescribing drugs to ensure the cytochrome P450 system can handle it. When a human is healthy enough then the dosage information is accurate and administering the drug is faster.

However, each substance has the ability to affect the processing time. Some drugs may metabolize faster and others are slower. For a person who has liver problems and health conditions then the cytochrome P450 may not process the drugs ingested normally or cannot metabolize as they should.

CBD in the Cytochrome P-450 System

For cannabidiol, it can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, this result in an overall increase in processing times.  The CBD oil is not the only one which has an effect on drug metabolism. The Grapefruit, watercress, St. John’s Wort, and goldenseal all have the same contact in the Cytochrome P-450 system.

If this is the case the Cytochrome P-450 results to higher levels of certain drugs in the system all at once. It may lead to adverse effects and even overdose. Hence, it‘s why it is recommended to consult a doctor first before taking CBD oil and other drugs. It may require the doctor to give specific safety dosage that both drugs can be used safely at the same time.

Drugs Compatible with CBD

As stated by the Indiana University Department of Medicine the drugs known to use Cyp40 system includes: 

•    Anesthetics

•    Antipsychotics

•    Antidepressants

•    Anti-epileptics

•    Sulfonylureas

•    Steroids

•    HMG CoA reductase inhibitors

•    Calcium channel blockers

•    Antihistamines

•    Prokinetics

•    HIV antivirals

•    Immune modulators

•    Beta-blockers

•    PPIs

•    NSAIDs

•    Angiotensin II blockers

•    Oral hypoglycemic agents

•    Benzodiazepines

•    Antiarrhythmics

•    Antibiotics

The list doesn’t imply that it can cause problems with cannabidiol or cause major risk. However, to be on the safe side, it might have a potential and advisable to consult a medical professional before using these drugs with CBD oil.

Some medications like “prodrugs” which are drugs that need to metabolize to bring therapeutic compound. This means once the drug is ingested as an inactive compound, the drug will then be processed as an active drug. If the process needs the help of CyP3A4 (part of the larger CyP450 system), then inhibitors will lessen the amount of the active drug in the body. This occurrence will then have a less therapeutic effect on a person.

Now, we understood the basic knowledge of how the drug is processed in the body. It is still important to consult a specialist when using CBD oil for medical purpose and as a food product. Each person may have a different effect of CBD in the body and can produce side effects when not careful.